Toxicology
Table of Contents
Introduction
Ellen K. Silbergeld, Chapter Editor
General Principles of Toxicology
Definitions and Concepts
Bo Holmberg, Johan Hogberg and Gunnar Johanson
Toxicokinetics
Dušan Djuríc
Target Organ And Critical Effects
Marek Jakubowski
Effects Of Age, Sex And Other Factors
Spomenka Telišman
Genetic Determinants Of Toxic Response
Daniel W. Nebert and Ross A. McKinnon
Mechanisms of Toxicity
Introduction And Concepts
Philip G. Watanabe
Cellular Injury And Cellular Death
Benjamin F. Trump and Irene K. Berezesky
Genetic Toxicology
R. Rita Misra and Michael P. Waalkes
Immunotoxicology
Joseph G. Vos and Henk van Loveren
Target Organ Toxicology
Ellen K. Silbergeld
Toxicology Test Methods
Biomarkers
Philippe Grandjean
Genetic Toxicity Assessment
David M. DeMarini and James Huff
In Vitro Toxicity Testing
Joanne Zurlo
Structure Activity Relationships
Ellen K. Silbergeld
Regulatory Toxicology
Toxicology In Health And Safety Regulation
Ellen K. Silbergeld
Principles Of Hazard Identification - The Japanese Approach
Masayuki Ikeda
The United States Approach to Risk Assessment Of Reproductive Toxicants and Neurotoxic Agents
Ellen K. Silbergeld
Approaches To Hazard Identification - IARC
Harri Vainio and Julian Wilbourn
Appendix - Overall Evaluations of Carcinogenicity to Humans: IARC Monographs Volumes 1-69 (836)
Carcinogen Risk Assessment: Other Approaches
Cees A. van der Heijden
Tables
- Examples of critical organs & critical effects
- Basic effects of possible multiple interactions of metals
- Haemoglobin adducts in workers exposed to aniline & acetanilide
- Hereditary, cancer-prone disorders & defects in DNA repair
- Examples of chemicals that exhibit genotoxicity in human cells
- Classification of tests for immune markers
- Examples of biomarkers of exposure
- Pros & cons of methods for identifying human cancer risks
- Comparison of in vitro systems for hepatotoxicity studies
- Comparison of SAR & test data: OECD/NTP analyses
- Regulation of chemical substances by laws, Japan
- Test items under the Chemical Substance Control Law, Japan
- Chemical substances & the Chemical Substances Control Law
- Selected major neurotoxicity incidents
- Examples of specialized tests to measure neurotoxicity
- Endpoints in reproductive toxicology
- Comparison of low-dose extrapolations procedures
- Frequently cited models in carcinogen risk characterization